Development of quantitative structure–activity relationship (QSAR) models to predict the carcinogenic potency of chemicals
作者: Raghuraman VenkatapathyChing Yi WangRobert Mark BruceChandrika Moudgal
作者单位: 1Pegasus Technical Services, Inc., 46 E. Hollister St., Cincinnati, OH 45219, USA
2National Center for Environmental Assessment, U.S. Environmental Protection Agency, 26 W Martin Luther King Drive, Cincinnati, OH 45268, USA
3National Homeland Security Research Center, U.S. Environmental Protection Agency, Region 7, ENSV/IO, 901 N 5th Street, Kansas City, KS 66101, USA
刊名: Toxicology and Applied Pharmacology, 2008, Vol.234 (2), pp.209-221
来源数据库: Elsevier Journal
DOI: 10.1016/j.taap.2008.09.028
关键词: Carcinogenic potencyToxicity Prediction by Komputer Assisted Technology (TOPKAT)Cancer Potency Database (CPDB)Lethal Dose (LD 50 )Maximum Tolerated Dose (MTD)Oral Slope Factor (OSF)Tumor Dose (TD 50 )MutagenicityOctanol–Water Partition Coefficient (logP)Classification and Regression Trees (CART)
原始语种摘要: Abstract(#br)Determining the carcinogenicity and carcinogenic potency of new chemicals is both a labor-intensive and time-consuming process. In order to expedite the screening process, there is a need to identify alternative toxicity measures that may be used as surrogates for carcinogenic potency. Alternative toxicity measures for carcinogenic potency currently being used in the literature include lethal dose (dose that kills 50% of a study population [LD 50 ]), lowest-observed-adverse-effect-level (LOAEL) and maximum tolerated dose (MTD). The purpose of this study was to investigate the correlation between tumor dose (TD 50 ) and three alternative toxicity measures as an estimator of carcinogenic potency. A second aim of this study was to develop a Classification and Regression Tree...
全文获取路径: Elsevier  (合作)
影响因子:3.975 (2012)

  • potency 潜力
  • carcinogenic 致癌的
  • QSAR 排队顺序访问复位
  • chemicals 化学药品
  • toxicity 毒性
  • alternative 可选择的
  • experimental 实验的
  • predict 预见
  • measures 层组
  • mutagenicity 诱变性