Novel mechanisms of antiprogestin action
作者: Kathryn B. HorwitzLin TungGlenn S. Takimoto
作者单位: 1University of Colorado Health Sciences Center, Department of Medicine, Division of Endocrinology, 4200 East Ninth Avenue, Campus Box B151, Denver, CO 80262, U.S.A.
2University of Colorado Health Sciences Center, Department of Pathology, Division of Endocrinology, 4200 East Ninth Avenue, Campus Box B151, Denver, CO 80262, U.S.A.
3University of Colorado Health Sciences Center, Department of The Molecular Biology Program, Division of Endocrinology, 4200 East Ninth Avenue, Campus Box B151, Denver, CO 80262, U.S.A.
刊名: Journal of Steroid Biochemistry and Molecular Biology, 1995, Vol.53 (1), pp.9-17
来源数据库: Elsevier Journal
DOI: 10.1016/0960-0760(95)00035-X
原始语种摘要: Abstract(#br)When hormone antagonists have unexpected agonist-like effects, the clinical consequences are grave. We describe novel molecular mechanisms by which antiprogestin-occupied progesterone receptors behave like agonists. These mechanisms include agonist-like transcriptional effects that do not require receptor binding to DNA at progesterone response elements, or that result from cross-talk between progesterone receptor and other signalling pathways. We discuss the complex structural organization of progesterone receptors and demonstrate that the B-receptor isoform has a unique third activation domain that may confer agonist-like properties in the presence of antiprogestins. By contrast, the A-receptor isoform is a dominant-negative inhibitor. We argue that these novel mechanisms...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • progesterone 孕酮
  • receptor 接受体
  • agonist 织肌
  • unexpected 突然的
  • breast 胸部
  • hormone 激素
  • novel 长篇小说
  • structural 构造
  • occupied 被占用的
  • argue 证明