Improved anticancer effect of ginseng extract by microwave-assisted processing through the generation of ginsenosides Rg3, Rg5 and Rk1
作者: Pilju ChoiJun Yeon ParkTaejung KimSoon-Hye ParkHo-kyong KimKi Sung KangJungyeob Ham
作者单位: 1KIST Gangneung Institute of Natural Products, Korea Institute of Science and Technology, Gangneung 210-340, Republic of Korea
2College of Korean Medicine, Gachon University, Seongnam 461-701, Republic of Korea
3Richwood Pharmaceutical Co., LTD., Seoul 100-704, Republic of Korea
刊名: Journal of Functional Foods, 2015, Vol.14 , pp.613-622
来源数据库: Elsevier Journal
DOI: 10.1016/j.jff.2015.02.038
关键词: GinsengMicrowaveGinsenosideCervical cancerCell death
原始语种摘要: Abstract(#br)In this study, we demonstrated the efficient structural conversion of ginsenosides, which enhances the anticancer activity of ginseng by microwave irradiation. The microwave-irradiated product of ginseng (MG) had a higher content of ginsenosides, Rg3+Rg5+Rk1, particularly Rg5 and Rk1, and, thus, has an increased medicinal effect. To confirm the anticancer effect of MG, it was tested in 5 human cancer cell lines (cervical cancer HeLa, gastric cancer AGS, colon cancer HCT-116, lung cancer A549, and liver cancer HepG2 cells). Anti-proliferation results for 5 human cancer cell lines treated with ginseng extracts indicate that HeLa cells treated with MG showed the highest activity with an IC 50 value of 130.1 µg/mL. MG also suppressed the growth of human cervical cancer cell...
全文获取路径: Elsevier  (合作)
影响因子:2.632 (2012)

  • ginseng 人参
  • anticancer 抗癌的
  • effect 效应
  • extract 提取
  • microwave 微波
  • cervical 颈的
  • medicinal 医学的
  • processing 加工
  • treated 加工的
  • induction 诱发