The role of microglia mediated pyroptosis in neonatal hypoxic-ischemic brain damage
作者: Yuan LvBin SunXing-xing LuYan-lin LiuMei LiLi-Xiao XuChen-Xi FengXin DingXing Feng
作者单位: 1Department of Neonatology, Children's Hospital of Soochow University, Suzhou, 215025, China
2Department of Neonatology, Northern Jiangsu People's Hospital, Yangzhou, 225000, China
3Department of Pediatrics Research Institute, Children's Hospital of Soochow University, Suzhou, 215025, China
刊名: Biochemical and Biophysical Research Communications, 2020, Vol.521 (4), pp.933-938
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbrc.2019.11.003
关键词: NLRP-3PyroptosisMicrogliaNeonatalHypoxic-ischemic brain damageMCC950
英文摘要: Abstract(#br)Neonatal hypoxic-ischemic encephalopathy (HIE) often leads to neonatal death or severe, irreversible neurological deficits. Pathologically, the occurrence of massive cell death and subsequent inflammation suggested that pyroptosis, an inflammation associated programed cell death, might play a role in HIE. Here, by measuring changes of key molecules in pyroptosis pathway in HIE patients, we discovered that their elevation levels tightly correlate with the severity of HIE. Next, we demonstrated that application of MCC950, a small molecule to inhibit NLRP3 inflammasome and thus pyroptosis, substantially alleviated pyroptosis and the injury severity in rats with neonatal hypoxic-ischemic brain damage (HIBD). Mechanistically, we showed that NLRP-3/caspase-1/GSDMD axis is required...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • neonatal 新生儿的
  • hypoxic 含氧量低的
  • microglia 小神经胶质细胞
  • ischemic 福尔克曼氏麻痹
  • brain 
  • damage 损伤