A voxel-based morphometric MRI study of stabilized obsessive–compulsive adolescent patients
作者: Luisa LázaroJosefina Castro-FornielesClàudia CullellSusana AndrésCarles FalcónRosa CalvoNuria Bargalló
作者单位: 1Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic Universitari, Barcelona, Spain
2IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Barcelona, Spain
3Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain
5Image Diagnostic Center, Hospital Clínic, Barcelona, Spain
6CIBER-BBN Research Network, Spain
刊名: Progress in Neuropsychopharmacology & Biological Psychiatry, 2011, Vol.35 (8), pp.1863-1869
来源数据库: Elsevier Journal
DOI: 10.1016/j.pnpbp.2011.07.016
关键词: AdolescentsNeuroimagingObsessive–compulsive disorderStatistical parametric mapping
原始语种摘要: Abstract(#br)Background(#br)The aim of this study was to determine whether treated stabilized adolescents with obsessive–compulsive disorder (OCD) present brain structure differences in comparison with healthy control subjects.(#br)Methods(#br)Twenty-seven adolescents with already-treated OCD and 27 healthy controls matched by age, sex and estimated intellectual level were assessed by means of psychopathological scales and magnetic resonance imaging (MRI). Axial three-dimensional T1-weighted images were obtained in a 1.5T scanner and analyzed using optimized voxel-based morphometry (VBM).(#br)Results(#br)Compared with controls, stabilized patients with OCD did not present any statistical differences in the whole brain. However, a small volume correction analysis yielded...
全文获取路径: Elsevier  (合作)

  • compulsive 强制的
  • stabilized 稳定的
  • adolescent 青年
  • controls 控制机构
  • disorder 无序
  • voxel 体元
  • cortex 皮层
  • matched 匹配的
  • correction 校正
  • significant 有效的