7α-Hydroxypregnenolone regulating locomotor behavior identified in the brain and pineal gland across vertebrates
作者: Kazuyoshi TsutsuiShogo HaraguchiHubert Vaudry
作者单位: 1Laboratory of Integrative Brain Sciences, Department of Biology and Center for Medical Life Science, Waseda University, Tokyo 162-8480, Japan
2Department of Biochemistry, Showa University School of Medicine, Tokyo 142-8555, Japan
3INSERM U1239, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Normandy University, 76000 Rouen, France
刊名: General and Comparative Endocrinology, 2018, Vol.265 , pp.97-105
来源数据库: Elsevier Journal
DOI: 10.1016/j.ygcen.2017.09.014
关键词: 7α-Hydroxypregnenolone (7α-OH PREG)DopamineMelatoninProlactinCorticosteroneBrainPituitary glandPineal gland
英文摘要: Abstract(#br)The brain synthesizes steroids de novo from cholesterol, which are called neurosteroids. Based on extensive studies on neurosteroids over the past thirty years, it is now accepted that neurosteroidogenesis in the brain is a conserved property across vertebrates. However, the formation of bioactive neurosteroids in the brain is still incompletely elucidated in vertebrates. In fact, we recently identified 7α-hydroxypregnenolone (7α-OH PREG) as a novel bioactive neurosteroid stimulating locomotor behavior in the brain of several vertebrates. The follow-up studies have demonstrated that the stimulatory action of brain 7α-OH PREG on locomotor behavior is mediated by the dopaminergic system across vertebrates. More recently, we have further demonstrated that the pineal gland, an...
全文获取路径: Elsevier  (合作)
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影响因子:2.823 (2012)

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关键词翻译
关键词翻译
  • gland 
  • pineal 松果体
  • locomotor 运动器
  • regulating 蝶的
  • brain 
  • across 横过
  • behavior 行为