Prevention of Hypoxia-Induced Apoptosis by the Angiogenic Factor Thymidine Phosphorylase
作者: Masaki KitazonoYuji TakebayashiKenji IshitsukaSonshin TakaoAyako TaniTatsuhiko FurukawaKazutaka MiyaderaYuji YamadaTakashi AikouShin-ichi Akiyama
作者单位: 1Department of Cancer Chemotherapy, Institute for Cancer Research, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima, 890-8520, Japan
2First Department of Surgery, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima, 890-8520, Japan
3Second Department of Internal Medicine, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima, 890-8520, Japan
4Taiho Pharmaceutical Company Ltd. Saitama, 357, Japan
刊名: Biochemical and Biophysical Research Communications, 1998, Vol.253 (3), pp.797-803
来源数据库: Elsevier Journal
DOI: 10.1006/bbrc.1998.9852
原始语种摘要: Abstract(#br)The angiogenic factor platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) is expressed at higher levels in a wide variety of solid tumors compared to adjacent normal tissues. Patients with PD-ECGF/TP-positive colon and esophageal tumors have a poorer prognosis than those with negative tumors. The expression of PD-ECGF/TP is a prognostic factor independent of microvessel density suggesting that TP has effects on tumor progression independent of its angiogenic activity. Evidence that hypoxia and apoptosis affect tumor growth prompted us to determine whether increased expression of PD-ECGF/TP prevents apoptosis induced by hypoxia. KB/TP cells transfected with a PD-ECGF/TP cDNA were resistant to hypoxia-induced apoptosis. Among the degradation...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • thymidine 胸腺嘧啶
  • hypoxia 氧过少
  • induced 感应的
  • deoxy 脱氧
  • degradation 减嚣夷酌
  • ribose 核糖
  • resistant 耐久的
  • apoptosis 细胞死
  • concentration 浓度
  • products 制品