Endozepines and their receptors: Structure, functions and pathophysiological significance
作者: Marie-Christine TononHubert VaudryJulien ChuquetFlorent GuillebaudJinjiang FanOlfa Masmoudi-KoukiDavid VaudryDamien LanfrayFabrice MorinVincent PrevotVassilios PapadopoulosJean-Denis TroadecJérôme Leprince
作者单位: 1Normandy University, Neuronal and Neuroendocrine Differentiation and Communication, Inserm U1239, Rouen, France
2Normandy University, Regional Platform for Cell Imaging of Normandy (PRIMACEN), Institute for Research and Innovation in Biomedicine (IRIB), Rouen, France
3Aix Marseille University, Cognitive Neuroscience Laboratory (LNC), UMR CNRS 7291, Marseille, France
4McGill University, The Research Institute of the McGill University Health Centre and Department of Medicine, Montreal, Quebec, Canada
5University Tunis El Manar, Faculty of Sciences of Tunis, LR18ES03, Laboratory of Neurophysiology, Cellular Physiopathology and Biomolecule Valorisation, Tunis, Tunisia
6University of Lille, Development and Plasticity of the Neuroendocrine Brain, Inserm U1172, CHU Lille, School of Medicine, Lille, France
7University of Southern California, Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, Los Angeles, CA, United States of America
刊名: Pharmacology and Therapeutics, 2020, Vol.208
来源数据库: Elsevier Journal
DOI: 10.1016/j.pharmthera.2019.06.008
关键词: Diazepam-binding inhibitorAcyl-CoA-binding proteinOctadecaneuropeptideTriakontatetraneuropeptideBenzodiazepinesTranslocator protein
原始语种摘要: Abstract(#br)The existence of specific binding sites for benzodiazepines (BZs) in the brain has prompted the search for endogenous BZ receptor ligands designated by the generic term « endozepines ». This has led to the identification of an 86-amino acid polypeptide capable of displacing [ 3 H]diazepam binding to brain membranes, thus called diazepam-binding inhibitor (DBI). It was subsequently found that the sequence of DBI is identical to that of a lipid carrier protein termed acyl-CoA-binding protein (ACBP). The primary structure of DBI/ACBP has been well preserved, suggesting that endozepines exert vital functions. The DBI / ACBP gene is expressed by astroglial cells in the central nervous system, and by various cell types in peripheral organs. Endoproteolytic cleavage of DBI/ACBP...
全文获取路径: Elsevier  (合作)
影响因子:7.793 (2012)

  • protein 蛋白质
  • binding 装订
  • diazepam 安定
  • DBI Data Base Interface
  • translocator 易位体
  • neuropeptide 神经肽
  • exert 发挥
  • regulated 规定
  • significance 显著性
  • peripheral 周边的