Lichen butyrolactone derivatives disrupt oral bacterial membrane
作者: Alaa SweidanImen SmidaMarylène Chollet-KruglerAurélie SauvagerJulien ValletNicolas GouaultNolwenn OlivieroZohreh Tamanai-ShacooriAgnès BurelPierre van de WegheAli ChokrSophie TomasiLatifa Bousarghin
作者单位: 1INSERM, Univ. Rennes, INRA, CHU Rennes, Nutrition Metabolisms and Cancer (NuMeCan), UMR-1241, Biosit, MRic/ISFR, Rennes, France
2UMR CNRS 6226, Institut des Sciences Chimiques de Rennes, Equipe CORINT, Chimie Organique et Interfaces, Univ. Rennes 1, Univ. Bretagne Loire, 2 Avenue du Pr. Léon Bernard, F-35043 Rennes, France
3Laboratory of Microbiology, Department of Life and Earth Sciences, Faculty of Sciences I, Lebanese University, Hadath Campus, Beirut, Lebanon
4Inserm U1242, Chemistry Oncogenesis Stress Signaling (COSS), Univ. Bretagne Loire, 2 Avenue du Pr. Léon Bernard, F-35043 Rennes, France
5Plateforme microscopie électronique MRic, Campus Santé, Rennes 1, France
刊名: Fitoterapia, 2019, Vol.137
来源数据库: Elsevier Journal
DOI: 10.1016/j.fitote.2019.104274
关键词: LichenButyrolactoneStreptococcus gordoniiPorphyromanas gingivalisCell wall
原始语种摘要: Abstract(#br)We have previously demonstrated that out of the butyrolactones series synthesized based on the natural lichen metabolite lichesterinic acid, compound ( B-13 ) was the most effective against oral bacteria. However, its antibacterial mechanism is still unknown. In this study, we have investigated its bacterial localization by synthesizing a fluorescently labeled B-13 with NBD while maintaining its antibacterial activity. We showed that this compound binds to Streptococcus gordonii cell surface, as demonstrated by HPLC analysis. By adhering to cell surface, B-13 induced cell wall disruption leading to the release of bacterial constituents and consequently, the death of S. gordonii , a Gram-positive bacterium. A Gram-negative counterpart, Porphyromanas gingivalis , showed also...
全文获取路径: Elsevier  (合作)
影响因子:2.231 (2012)

  • butyrolactone 丁内酯
  • disrupt 爆喷
  • bacterial 细菌的
  • membrane 
  • derivatives 派生物