CXCL12/CXCR4 signal transduction in diseases and its molecular approaches in targeted-therapy
作者: Ashraf Mousavi
作者单位: 1Independent Researcher
刊名: Immunology Letters, 2020, Vol.217 , pp.91-115
来源数据库: Elsevier Journal
DOI: 10.1016/j.imlet.2019.11.007
关键词: ChemokinesCXCL12/CXCR4 axisCancerAutoimmune diseasesSignaling pathwaysTargeted-therapy
原始语种摘要: Abstract(#br)Chemokines are small molecules called “chemotactic cytokines” and regulate many processes like leukocyte trafficking, homing of immune cells, maturation, cytoskeletal rearrangement, physiology, migration during development, and host immune responses. These proteins bind to their corresponding 7-membrane G-protein-coupled receptors. Chemokines and their receptors are anti-inflammatory factors in autoimmune conditions, so consider as potential targets for neutralization in such diseases. They also express by cancer cells and function as angiogenic factors, and/or survival/growth factors that enhance tumor angiogenesis and development. Among chemokines, the CXCL12/CXCR4 axis has significantly been studied in numerous cancers and autoimmune diseases. CXCL12 is a homeostatic...
全文获取路径: Elsevier  (合作)
影响因子:2.337 (2012)

  • transduction 转导
  • autoimmune 自身免疫的
  • targeted 对准目标的
  • homeostatic 恒定性的
  • neutralizing 中和
  • chemotactic 趋化性的
  • neutralization 中和
  • cytokines 细胞浆移动
  • potential 
  • leukocyte 白血球