Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice
作者: Shanshan ZhangXinhua SongDan CaoZhong XuBiao FanLi CheJunjie HuBin ChenMingjie DongMaria G. PiloAntonio CiglianoKatja EvertSilvia RibbackFrank DombrowskiRosa M. PascaleAntonio CossuGianpaolo VidiliAlberto PorcuMaria M. SimileGiovanni M. PesGianluigi GiannelliJohn GordanLixin WeiMatthias EvertWenming CongDiego F. CalvisiXin Chen
作者单位: 1Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
2Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
3Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China
4Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China
5Department of Gastroenterology, Guizhou Provincial People's Hospital, Guizhou, China
6Department of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital & Institute, Beijing, China
7Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA, USA
8School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, Hubei, China
9Department of Pediatrics and Institute for Computational Health Sciences, University of California, San Francisco, CA, USA
10Department of Gastroenterology, 307 Hospital of PLA, Beijing, China
11Institute of Pathology, University of Greifswald, Greifswald, Germany
12Institute of Pathology, University of Regensburg, Regensburg, Germany
13Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy
14Unit of Pathology, Azienda Ospedaliero Universitaria Sassari, Sassari, Italy
15National Institute of Gastroenterology “S. de Bellis”, Research Hospital, Castellana Grotte, Italy
16Department of Medicine, University of California, San Francisco, CA, USA
刊名: Journal of Hepatology, 2017
来源数据库: Elsevier Journal
DOI: 10.1016/j.jhep.2017.07.006
关键词: Intrahepatic cholangiocarcinomaDual mTOR inhibitorTargeted therapyGemcitabineTranslational medicineMouse modelMLN0128
英文摘要: Background & Aims(#br)Intrahepatic cholangiocarcinoma (ICC) is a lethal malignancy without effective treatment options. MLN0128, a second generation pan-mTOR inhibitor, shows efficacy for multiple tumor types. We evaluated the therapeutic potential of MLN0128 vs. gemcitabine/oxaliplatin in a novel ICC mouse model.(#br)Methods(#br)We established a novel ICC mouse model via hydrodynamic transfection of activated forms of AKT (myr-AKT) and Yap (YapS127A) protooncogenes (that will be referred to as AKT/YapS127A). Genetic approaches were applied to study the requirement of mTORC1 and mTORC2 in mediating AKT/YapS127A driven tumorigenesis. Gemcitabine/oxaliplatin and MLN0128 were administered in AKT/YapS127A tumor-bearing mice to study their anti-tumor efficacy in vivo . Multiple human ICC cell...
全文获取路径: Elsevier  (合作)
影响因子:9.858 (2012)

  • intrahepatic 肝内的
  • inhibitor 抑制剂
  • effective 有效的
  • against 反对
  • therapy 治疗
  • medicine 
  • model 模型