Investigating methotrexate toxicity within a randomized double-blinded, placebo-controlled trial: Rationale and design of the Cardiovascular Inflammation Reduction Trial-Adverse Events (CIRT-AE) Study
作者: Jeffrey A. SparksMedha BarbhaiyaElizabeth W. KarlsonSusan Y. RitterSoumya RaychaudhuriCassandra C. CorriganFengxin LuJacob SelhubDaniel I. ChasmanNina P. PaynterPaul M. RidkerDaniel H. Solomon
作者单位: 1Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women׳s Hospital, Boston, MA
2Harvard Medical School, Boston, MA
3Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA
4Jean Mayer USDA, Human Nutrition Center on Aging, Tufts University, Boston, MA
5Department of Medicine, Center for Cardiovascular Disease Prevention, Brigham and Women׳s Hospital, Boston, MA
刊名: Seminars in Arthritis and Rheumatism, 2017
来源数据库: Elsevier Journal
DOI: 10.1016/j.semarthrit.2017.02.003
关键词: MethotrexateToxicityPharmacovigilanceGeneticsPolyglutamate
原始语种摘要: Abstract(#br)Background(#br)The role of low dose methotrexate (LDM) in potential serious toxicities remains unclear despite its common use. Prior observational studies investigating LDM toxicity compared LDM to other active drugs. Prior placebo-controlled clinical trials of LDM in inflammatory conditions were not large enough to investigate toxicity. The Cardiovascular Inflammation Reduction Trial (CIRT) is an ongoing NIH-funded, randomized, double-blind, placebo-controlled trial of LDM in the secondary prevention of cardiovascular disease. We describe here the rationale and design of the CIRT-Adverse Events (CIRT-AE) ancillary study which aims to investigate adverse events within CIRT.(#br)Design(#br)CIRT will randomize up to 7000 participants with cardiovascular disease and no systemic...
全文获取路径: Elsevier  (合作)
影响因子:3.806 (2012)

  • controlled 受控
  • methotrexate 氨甲喋呤
  • trial 试验
  • placebo 无效对照药
  • toxicity 毒性
  • Reduction 还原
  • events 定时
  • cardiovascular 心血管的
  • adverse 逆的
  • within 在以内