Byakangelicin as a modulator for improved distribution and bioactivity of natural compounds and synthetic drugs in the brain
作者: Yoon Young KangJihyeon SongJun Yeong KimHeesun JungWoon-Seok YeoYoongho LimHyejung Mok
作者单位: 1Department of Bioscience and Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea
刊名: Phytomedicine, 2019, Vol.62
来源数据库: Elsevier Journal
DOI: 10.1016/j.phymed.2019.152963
关键词: ByakangelicinEx vivo monitoringCompound mixtureSynergistic biodistributionBrain
原始语种摘要: Abstract(#br)Background(#br)The elucidation of the biological roles of individual active compounds in terms of their in vivo bio-distribution and bioactivity could provide crucial information to understand how natural compounds work together as treatments for diseases.(#br)Purpose(#br)We examined the functional roles of Byakangelicin (Byn) to improve the brain accumulation of active compounds, e.g. , umbelliferone (Umb), curcumin (Cur), and doxorubicin (Dox), and consequently to enhance their biological activities.(#br)Methods(#br)Active compounds were administered intravenously to mice, with or without Byn, after which organs were isolated and visualized for their ex vivo fluorescence imaging to determine the bio-distribution of each active compound in vivo . For the in vivo bioactivity,...
全文获取路径: Elsevier  (合作)
影响因子:2.972 (2012)

  • bioactivity 生物活性
  • brain 
  • compounds 化合物
  • active 活动的
  • distribution 分布
  • improved 改进
  • addition 添加
  • functional 功能的
  • organs 男生殖器
  • demonstrated 探明的储量