Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects
作者: Rita NemrAmira TurkiAkram EchtayGhadeer S. Al-ZabenHoda S. DaherNoha A. Irani-HakimeSose H. KeleshianWassim Y. Almawi
作者单位: 1Department of Endocrinology, University Medical Center Rizk Hospital, Beirut, Lebanon
2Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia
3Department of Endocrinology, Rafic Hariri University Hospital, Beirut, Lebanon
4Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain
5Department of Laboratory Medicine, St. Georges University Hospital, Beirut, Lebanon
刊名: Diabetes Research and Clinical Practice, 2012, Vol.98 (3), pp.e23-e27
来源数据库: Elsevier Journal
DOI: 10.1016/j.diabres.2012.09.044
关键词: DiabetesGenome wide associationReplicationTCF7L2
原始语种摘要: Abstract(#br)We tested the association of TCF7L2 variants with type 2 diabetes (T2DM) in 691 Lebanese people and 919 controls. rs7901695, rs4506565, rs7903146, rs12243326, rs7895340, and rs12255372 minor allele frequencies were higher in T2DM. Haplotype analysis (rs7901695–rs4506565–rs7903146–rs12243326–rs7895340–rs11196205–rs12255372) identified positively- (2122112, 2222222) and negatively- (1111111) T2DM-associated haplotypes. TCF7L2 is a common T2DM candidate gene in Lebanese people.
全文获取路径: Elsevier  (合作)
影响因子:2.741 (2012)

  • diabetes 糖尿病
  • associated 相关的
  • TCF Trim Centering and Feel
  • strongly 强烈地
  • candidate 选择物
  • higher 
  • negatively 否定地
  • association 联合
  • controls 控制机构
  • factor 因素