Sigma-1 receptor activation ameliorates LPS-induced NO production and ROS formation through the Nrf2/HO-1 signaling pathway in cultured astrocytes
作者: Ying WangChuan-Sheng Zhao
作者单位: 1Department of Neurology, The first affiliated hospital of China Medical University, Shenyang, China
2Department of Neurology, The first affiliated hospital of Dalian Medical University, Dalian, China
刊名: Neuroscience Letters, 2019, Vol.711
来源数据库: Elsevier Journal
DOI: 10.1016/j.neulet.2019.134387
关键词: AstrocytesSig-1ROxidative/nitrosative stressNrf2/HO-1 signaling
原始语种摘要: Abstract(#br)Accumulating evidence has shown that astrocytes play a critical role in neuroinflammation and protection against oxidative stress. In this study, we investigated the effects of sigma-1 receptor (Sig-1R) activation on lipopolysaccharide (LPS)-induced inflammatory reactions and oxidative/nitrosative stress in cultured astrocytes. We found that SA4503, a selective Sig-1R agonist, attenuated LPS-induced inflammatory reactions and oxidative/nitrosative stress by downregulating the expression of iNOS and tumor necrosis factor α (TNF-α) and upregulating glutathione (GSH) in cultured astrocytes. To investigate the mechanism by which SA4503 caused these effects, we then examined the expression of nuclear factor erythroid-derived 2-like 2 (Nrf2) and heme oxygenase-1 (HO-1) through...
全文获取路径: Elsevier  (合作)
影响因子:2.026 (2012)

  • induced 感应的
  • activation 活化
  • LPS Laboratory Peripheral System
  • Sigma 西格马牌手表
  • cultured 人工培养的
  • receptor 接受体
  • pathway 轨道
  • signaling 发信号
  • inflammatory 激怒的
  • stress 应力