Mesenchymal stem cells-derived IL-6 activates AMPK/mTOR signaling to inhibit the proliferation of reactive astrocytes induced by hypoxic-ischemic brain damage
作者: Mulan HeXia ShiMiao YangTing YangTingyu LiJie Chen
作者单位: 1Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, China
2Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China
3China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing 400014, China
4Chongqing Stem Cell Therapy Engineering Technical Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, China
刊名: Experimental Neurology, 2018, Vol.311
来源数据库: Elsevier Journal
DOI: 10.1016/j.expneurol.2018.09.006
关键词: Astrocyte proliferationInterleukin-6Mammalian AMP-activated protein kinaseαMammalian target of rapamycinMesenchymal stem cellsHypoxic-ischemic brain damage
英文摘要: Abstract(#br)Mesenchymal stem cells (MSCs) treatment is an effective strategy for the functional repair of central nervous system (CNS) insults through the production of bioactive molecules. We have previously demonstrated that the interleukin-6 (IL-6) secreted by MSCs plays an anti-apoptotic role in injured astrocytes and partly promotes functional recovery in neonatal rats with hypoxic-ischemic brain damage (HIBD). However, the mechanisms of IL-6 underlying the proliferation of injured astrocytes have not been fully elucidated. In this study, we investigated the therapeutic effects of MSCs on astrocyte proliferation in neonatal rats subjected to HIBD. A HIBD model was established in Sprague Dawley (SD) rats, and MSCs were administered by intracerebroventricular injection 5 days after...
全文获取路径: Elsevier  (合作)
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影响因子:4.645 (2012)

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关键词翻译
关键词翻译
  • ischemic 福尔克曼氏麻痹
  • hypoxic 含氧量低的
  • cells 麻风细胞
  • reactive 电抗的
  • brain 
  • rapamycin 雷帕霉素
  • induced 感应的
  • protein 蛋白质
  • kinase 激酶
  • damage 损伤