Regular Aspirin Use and the Risk of Lethal Prostate Cancer in the Physicians’ Health Study
作者: Mary K. DownerChristopher B. AllardMark A. PrestonJ. Michael GazianoMeir J. StampferLorelei A. MucciJulie L. Batista
作者单位: 1Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
2Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
3Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
4Division of Urology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
5Department of Surgery, Joseph Brant Memorial Hospital, Burlington, ON, Canada
6Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
刊名: European Urology, 2017
来源数据库: Elsevier Journal
DOI: 10.1016/j.eururo.2017.01.044
关键词: AspirinLethal prostate cancerProstate cancer mortalityProstate cancer progression
原始语种摘要: Abstract(#br)Background(#br)Regular aspirin use probably protects against some malignancies including prostate cancer (PC), but its impact on lethal PC is particularly unclear.(#br)Objective(#br)To investigate the association between regular aspirin and (1) the risk of lethal PC in a large prospective cohort and (2) survival after PC diagnosis.(#br)Design, setting, and participants(#br)In 1981/82, the Physicians’ Health Study randomized 22 071 healthy male physicians to aspirin, β-carotene, both, or placebo. After the trial ended in 1988, annual questionnaires have obtained data on aspirin use, cancer diagnoses, and outcomes up to 2009 for the whole cohort, and to 2015 for PC patients.(#br)Outcome measurements and statistical analysis(#br)We evaluated the relationship between regular...
全文获取路径: Elsevier  (合作)
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影响因子:10.476 (2012)

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关键词翻译
关键词翻译
  • aspirin 阿司匹林
  • lethal 致死
  • associated 相关的
  • cohort 伙伴
  • prostate 前列腺
  • survival 生存
  • regular 均匀的
  • trial 试验
  • diagnosis 特镇述
  • cancer 癌症