The Influence of Age on the Histopathology and Prognosis of Atypical Breast Lesions
作者: Amanda R. SergesketterSamantha M. ThomasOluwadamilola M. FayanjuCarolyn S. MenendezLaura H. RosenbergerRachel A. GreenupTerry HyslopEdgardo R. Parrilla CastellarE. Shelley HwangJennifer K. Plichta
作者单位: 1Department of Surgery, Duke University Medical Center, Durham, North Carolina
2Duke Cancer Institute, Durham, North Carolina
3Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina
4Department of Pathology, Duke University Medical Center, Durham, North Carolina
刊名: Journal of Surgical Research, 2019, Vol.241 , pp.188-198
来源数据库: Elsevier Journal
DOI: 10.1016/j.jss.2019.03.047
关键词: AgeAtypical breast lesionsBreast atypiaBreast cancer risk
英文摘要: Abstract(#br)Background(#br)Although several prognostic variables and risk factors for breast cancer are age-related, the association between age and risk of cancer with breast atypia is controversial. This study aimed to compare the type of breast atypia and risk of underlying or subsequent breast cancer by age.(#br)Methods(#br)Adult women with breast atypia (atypical ductal hyperplasia, atypical lobular hyperplasia, and lobular carcinoma in situ ) at a single institution from 2008 to 2017 were stratified by age at initial diagnosis: <50 y, 50-70 y, and >70 y. Regression modeling was used to estimate the association of age with risk of underlying carcinoma or subsequent cancer diagnosis.(#br)Results(#br)A total of 530 patients with atypia were identified: 31.1% < 50 y ( n = 165), 58.1%...
全文获取路径: Elsevier  (合作)
影响因子:2.018 (2012)