Development of a Safe and Effective Pediatric Dosing Regimen for Sotalol Based on Population Pharmacokinetics and Pharmacodynamics in Children With Supraventricular Tachycardia
作者: Stephanie LäerJan-Peer ElshoffBernd MeibohmJochen WeilThomas S. MirWenhui ZhangMartin Hulpke-Wette
作者单位: 1Department of Clinical Pharmacy and Therapeutics, University Düsseldorf, Düsseldorf, Germany
2University of Tennessee Health Science Center, Department of Pharmaceutical Sciences, Memphis, Tennessee
3Department of Pediatric Cardiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
4Department of Pediatric Cardiology, University of Göttingen, Göttingen, Germany
刊名: Journal of the American College of Cardiology, 2005, Vol.46 (7), pp.1322-1330
来源数据库: Elsevier Journal
DOI: 10.1016/j.jacc.2005.06.061
原始语种摘要: Objectives(#br)The objective of this study was to develop age-specific dosage guidelines for sotalol in children with supraventricular tachycardia (SVT) based on a population pharmacokinetic covariate analysis, clinical trial simulations, and pharmacodynamics.(#br)Background(#br)A rapid onset of an effective and safe antiarrhythmic sotalol therapy, especially for infants and neonates, is frequently delayed because of age-dependent interpatient variability in pharmacokinetics and pharmacodynamics.(#br)Methods(#br)Pediatric patients with SVT (mean age 3.51 years [range 0.03 to 17 years]) were analyzed after oral sotalol doses of 1.0 to 9.9 mg/kg/day using population pharmacokinetic analysis and clinical trial simulation (n = 76), pharmacokinetic/pharmacodynamic modeling for QT interval...
全文获取路径: Elsevier  (合作)
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影响因子:14.086 (2012)

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关键词翻译
关键词翻译
  • sotalol 苏特罗
  • antiarrhythmic 抗心律失常的
  • prolongation 后加演化
  • effective 有效的
  • tachycardia 心搏过速
  • trough 凹槽
  • rhythm 韵律
  • dosage 放射剂量
  • years 年代
  • population 母体