Rapid screening of sulfonamides in dietary supplements based on extracted common ion chromatogram and neutral loss scan by LC-Q/TOF-mass spectrometry
作者: Nam-Yong KiJisu HurBeom Hee KimKyung Ho KimBong Jin MoonHan Bin OhJongki Hong
作者单位: 1College of Pharmacy, Kyung Hee University, Seoul 02447, South Korea
2College of Pharmacy, Kangwon National University, Chunchun 24341, South Korea
3Department of Chemistry, Sogang University, Seoul 04107, South Korea
刊名: Journal of Food and Drug Analysis, 2018
来源数据库: Elsevier Journal
DOI: 10.1016/j.jfda.2018.08.006
关键词: SulfonamidesDietary supplementsUHPLC-Q/TOF-MSExtracted common ion chromatogramNeutral loss scan
英文摘要: Abstract(#br)There is an increasing amount of dietary supplements that are adulterated with diuretics and anti-diabetic drugs; this has become a global problem due to the wide distribution of dietary supplements and the serious negative health effects of the adulterants. In this study, a rapid screening method was developed for detection and confirmation of 35 sulfonamides in supplements by ultra-high performance liquid chromatography quadrupole/time of flight mass spectrometry. For effective extraction of sulfonamides from dietary supplements, four extraction protocols including HLB and WAX solid-phase extraction, Quick Easy Cheap Effective Rugged and Safe method, and pH-controlled liquid–liquid extraction were evaluated, and pH-controlled liquid–liquid extraction method was shown to be...
全文获取路径: Elsevier  (合作)

  • sulfonamides 磺胺类药物
  • common 普通
  • spectrometry 光谱测定
  • neutral 中性的
  • dietary 饮食的
  • chromatogram 色谱图
  • Rapid 拉皮德牌照相机
  • screening 筛分
  • based 基于
  • TOF Time Of Filling