IS PLATELET PHOSPHOLIPID-DEPENDENT THROMBIN GENERATION ALTERED BY ACUTE MYOCARDIAL INFARCTION OR ASPIRIN?
作者: Simin RotaPaul D FlynnNicholas J WarehamTrevor P BaglinChristopher D Byrne
作者单位: 1Dept of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK
2Dept of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK
3Institute of Public Health, Dept of Community Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK
4Dept of Haematology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK
刊名: Thrombosis Research, 1996, Vol.83 (4), pp.329-338
来源数据库: Elsevier Journal
DOI: 10.1016/0049-3848(96)00141-7
关键词: platelet phospholipid-dependent thrombin generation myocardial infarction – aspirin
原始语种摘要: Abstract(#br)The ability of unactivated and calcium ionophore activated platelets to support thrombin generation in defibrinated plasma was measured by a chromogenic substrate assay in the absence of clot formation. Platelet phospholipid-dependent thrombin generation (Platelet-TG) could be measured using platelets isolated from blood collected into either sodium citrate or EDTA as anticoagulant. Measurements were stable in samples kept at room temperature for 24 hours after venesection. There was no significant difference in either the unactivated or activated platelet-TG with platelets collected into either anticoagulant (mean difference 10.12 nmol/min unactivated and 10.60 nmol/min activated). There was no correlation between unactivated and activated platelet-TG and patient age....
全文获取路径: Elsevier  (合作)
分享到:
来源刊物:
影响因子:3.133 (2012)

×
关键词翻译
关键词翻译
  • unactivated 未活化的
  • aspirin 阿司匹林
  • generation 世代
  • venesection 静脉切开术
  • infarction 梗塞
  • myocardial 心肌的
  • phospholipid 磷脂
  • either 任何
  • platelet 血小板
  • range 射程