Vascular tube formation and angiogenesis induced by polyvinylpyrrolidone-coated silver nanoparticles
作者: Kyeongah KangDae-Hyoun LimIn-Hong ChoiTaegyeong KangKangtaek LeeEun-Yi MoonYoung YangMyeong-Sok LeeJong-Seok Lim
作者单位: 1Department of Biological Science and the Research Center for Women's Disease, Sookmyung Women's University, Seoul, Republic of Korea
2Department of Microbiology, College of Medicine, Nanomedical National Core Research Center, Yonsei University, Seoul, Republic of Korea
3Department of Chemical Engineering, Yonsei University, Seoul, Republic of Korea
4Department of Bioscience and Biotechnology, Sejong University, Seoul, Republic of Korea
刊名: Toxicology Letters, 2011, Vol.205 (3), pp.227-234
来源数据库: Elsevier Journal
DOI: 10.1016/j.toxlet.2011.05.1033
关键词: Silver nanoparticlesMatrigel plugAngiogenesisVascular endothelial growth factorVEGF signaling
原始语种摘要: Abstract(#br)Silver nanoparticles (AgNPs) are one of the most commonly used nanomaterials due to their antibacterial properties. In this study, we examined the effects of polyvinylpyrrolidone (PVP)-coated AgNPs (average size 2.3nm) on angiogenesis in both an in vivo model and an in vitro endothelial cell line, SVEC4-10. Increased angiogenesis was detected around the injection site of AgNP-containing Matrigel in vivo . AgNPs also increased the infiltration of endothelial cells and the hemoglobin (Hb) content in AgNP-Matrigel plugs implanted into mice. AgNPs induced endothelial cell tube formation on growth factor-reduced Matrigel, production of reactive oxygen species (ROS), and production of angiogenic factors, such as vascular endothelial growth factor (VEGF) and...
全文获取路径: Elsevier  (合作)
影响因子:3.145 (2012)

  • silver 
  • formation 建造
  • angiogenesis 血管生成
  • induced 感应的
  • factor 因素
  • growth 生长
  • Silver 
  • coated 涂渍的
  • concentration 浓度
  • PVP 可编程序视频处理机