In vivo modulation of nucleus tractus solitarius (NTS) neurones by activation of 5-hydroxytryptamine 2 receptors in rats
作者: Caroline Sévoz-CoucheY WangA.G RamageK.M SpyerD Jordan
作者单位: 1Department of Physiology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
2Department of Pharmacology, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
刊名: Neuropharmacology, 2000, Vol.39 (11), pp.2006-2016
来源数据库: Elsevier Journal
DOI: 10.1016/S0028-3908(00)00055-1
关键词: Rat5-HT 2 receptorsIonophoresisBrainstemVagal afferents
原始语种摘要: Abstract(#br)In in vivo experiments, 5-hydroxytryptamine (5-HT) and (±)-2,5-dimethoxy-4-iodoamphetamine HCl (DOI), a 5-HT 2 receptor agonist, were applied by ionophoresis to rat nucleus tractus solitarius (NTS) neurones identified by their vagal and cardiopulmonary afferent inputs to test whether the response of NTS cells to 5-HT 2 receptor activation was related to whether they received mono- or polysynaptic vagal inputs and their presumed function as defined by their afferent input. Cells were classified on the basis of the variability of the latency of the vagal-evoked spikes: this varied by less than 3 ms for Group 1, from 3 to 5 ms for Group 2, and more than 5 ms for Group 3. Both 5-HT and DOI inhibited most Group 1 cells (16/18) and inactive (without ongoing activity) cells (8/13)...
全文获取路径: Elsevier  (合作)
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影响因子:4.114 (2012)

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关键词翻译
关键词翻译
  • NTS Naval Telecommunications System
  • tractus 
  • activation 活化
  • polysynaptic 多突触的
  • stimulation 激励
  • nucleus 晶核
  • vagal 迷走神经的
  • evoked 诱发的
  • reversed 倒转的
  • cells 麻风细胞