Time-resolved early-photon scheme for high-resolution fluorescence molecular tomography with perturbation Monte Carlo modeling: Experimental validations using a multichannel TCSPC system
作者: Wenbo WanLingling LiuYihan WangJiao LiLimin ZhangZhongxing ZhouZhuanping QinHuijuan ZhaoFeng Gao
作者单位: 1Tianjin University, School of Precision Instrument and Optoelectronics Engineering, Tianjin 300072, China
2Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China
3Tianjin University of Technology and Education, School of Automation and Electrical Engineering, Tianjin 300222, China
刊名: Infrared Physics and Technology, 2019, Vol.98 , pp.323-333
来源数据库: Elsevier Journal
DOI: 10.1016/j.infrared.2019.03.037
关键词: Fluorescence molecular tomographyEarly-photonPerturbation Monte CarloTime-resolved reconstructionMulti-channel TCSPC system
英文摘要: Abstract(#br)In near-infrared fluorescence molecular tomography (FMT), high turbidity of biological tissue exerts severe adversity to image reconstruction. In contrast to highly diffusive photons, early-photons preserve a significant amount of spatial information, and thereby considerably improve image quality by reducing ill-posedness in inversion processes. However, light propagation of early-photons is hard to be accurately modeled by the mathematically simple diffusion equation (DE), and the rich information in the time-resolved (TR) measurements has not been effectively utilized in reconstruction with the traditional single-gate (SG) data type. In order to take an advantage of the early-photons in time-domain FMT for in-vivo imaging of small animals, we have proposed an early-photon...
全文获取路径: Elsevier  (合作)
影响因子:1.364 (2012)

  • tomography 断层x 线摄影
  • modeling 制祝型
  • photon 光量子
  • reconstruction 复原
  • molecular 分子的
  • resolved 分辨
  • system 
  • scheme 略图
  • Fluorescence 荧光
  • perturbation 扰动