Protective effect of hypoxylonol C and 4,5,4′,5′-tetrahydroxy-1,1′-binaphthyl isolated from Annulohypoxylon annulatum against streptozotocin-induced damage in INS-1 cells
作者: Dahae LeePilju ChoiBuyng Su HwangTaejung KimYoungseok KimJin-Chul KimJi Hoon SongJung Sik ParkGwi Seo HwangNoriko YamabeKi Sung KangJungyeob Ham
作者单位: 1School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea
2College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea
3Natural Products Research Institute, Korea Institute of Science and Technology, 679 Saimdang-ro, Gangneung 25451, Republic of Korea
4Division of Bio-Medical Science and Technology, University of Science and Technology, Daejeon 34113, Republic of Korea
刊名: Bioorganic Chemistry, 2019, Vol.90
来源数据库: Elsevier Journal
DOI: 10.1016/j.bioorg.2019.103053
关键词: Annulohypoxylon annulatumPancreatic β-cellsApoptosisStreptozotocin
英文摘要: Abstract(#br)We evaluated the protective effects of hypoxylonol C and 4,5,4′,5′-tetrahydroxy-1,1′-binaphthyl (BNT) isolated from Annulohypoxylon annulatum on pancreatic β-cell apoptosis, using the β-cell toxin streptozotocin (STZ). Hypoxylonol C and BNT restored the STZ-induced decrease in INS-1 cell viability in a dose-dependent manner. In addition, treatment of INS-1 cells with 50 μM STZ resulted in an increase in apoptotic cell death, which was observed as annexin V fluorescence intensity. Apoptotic cell death was decreased by co-treatment with 100 μM hypoxylonol C and 100 μM BNT. Similarly, STZ caused a marked increase in the expression of cleaved caspase-8, caspase-3, Bax, and poly (ADP-ribose) polymerase (PARP), as well as a decrease in the expression of B-cell lymphoma 2 (Bcl-2),...
全文获取路径: Elsevier  (合作)
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影响因子:1.732 (2012)

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关键词翻译
关键词翻译
  • tetrahydroxy 四羟(基)的
  • streptozotocin 链脲佐菌素
  • cells 麻风细胞
  • induced 感应的
  • binaphthyl 联萘
  • effect 效应
  • against 反对
  • isolated 隔离
  • damage 损伤