Biphasic hierarchical extracellular matrix scaffold for osteochondral defect regeneration
作者: X. LinJ. ChenP. QiuQ. ZhangS. WangM. SuY. ChenK. JinA. QinS. FanP. ChenX. Zhao
作者单位: 1Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China
2Department of Pathophysiology, Wenzhou Medical University, Wenzhou, China
3Department of Orthopedics, Shanghai Key Laboratory of Orthopedic Implant, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
刊名: Osteoarthritis and Cartilage, 2018, Vol.26 (3), pp.433-444
来源数据库: Elsevier Journal
DOI: 10.1016/j.joca.2017.12.001
关键词: Extracellular matrixOsteoarthritisCartilageSubchondral boneOsteochondral defect
英文摘要: Summary(#br)Objective(#br)To investigate the effect of decellularized osteochondral extracellular matrix (ECM) scaffold for osteochondral defect regeneration.(#br)Design(#br)We compared the histological features and microstructure of degenerated cartilage to normal articular cartilage. We also generated and evaluated osteochondral ECM scaffolds through decellularization technology. Then scaffolds were implanted to osteochondral defect in rabbit model. After 12 weeks surgery, regeneration tissues were analyzed by histology, immunohistochemistry evaluation. And possible mechanisms of angiogenesis and cell migration were explored.(#br)Results(#br)We demonstrated decreased cell numbers, formation of fibrous cartilage, lost microstructure and worse permeability in degenerated cartilage...
全文获取路径: Elsevier  (合作)
影响因子:4.262 (2012)

  • hierarchical 分级
  • scaffold 脚手架
  • defect 缺陷
  • regeneration 再生
  • matrix 石基
  • extracellular 胞外的