Phase IIb, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Determine Effects of Elocalcitol in Women With Overactive Bladder and Idiopathic Detrusor Overactivity
作者: G. Alessandro DigesuElena VerdiLinda CardozoLorenza OlivieriVik KhullarEnrico Colli
作者单位: 1Department of Urogynaecology, St. Mary's Hospital, London, United Kingdom
2Bioxell, SpA, Milan, Italy
3Department of Urogynaecology, King's College Hospital, London, United Kingdom
刊名: Urology, 2012, Vol.80 (1), pp.48-54
来源数据库: Elsevier Journal
DOI: 10.1016/j.urology.2012.03.035
原始语种摘要: Objective(#br)To evaluate the efficacy and safety of elocalcitol in the treatment of women with overactive bladder and idiopathic detrusor overactivity.(#br)Methods(#br)The study was a multicenter, double-blind, randomized, placebo-controlled, parallel-group trial of women with overactive bladder symptoms recruited from 48 European tertiary referral centers. The participants were randomized to receive either placebo or elocalcitol, 75 μg/d or 150 μg/d for 4 weeks. A 3-day bladder diary, the Urgency Perception Scale, the Patient's Perception of Bladder Condition, and urodynamics were used before and after treatment. Vital signs, laboratory blood tests, 24-hour urine collection, and electrocardiography were also performed to assess the safety. The analysis of covariance test was used to...
全文获取路径: Elsevier  (合作)
影响因子:2.424 (2012)

  • overactive 过度活化
  • detrusor 排尿肌
  • overactivity 过度活化性
  • controlled 受控
  • urodynamics 尿动力学
  • bladder 膀胱
  • receiving 接收
  • placebo 无效对照药
  • treatment 处理
  • incontinence 失禁