Expression, polymorphism and methylation pattern of interleukin-6 in periodontal tissues
作者: Florença Abdanur StefaniMichelle Beatriz VianaAna Carolina DupimJoão Artur Ricieri BritoRicardo Santiago GomezJosé Eustáquio da CostaPaula Rocha Moreira
作者单位: 1Laboratory of Molecular Biology, Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
2Department of Periodontology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
3Laboratory of Cell-Cell Interactions, Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
刊名: Immunobiology, 2013, Vol.218 (7), pp.1012-1017
来源数据库: Elsevier Journal
DOI: 10.1016/j.imbio.2012.12.001
关键词: Gene expressionInterleukin-6MethylationPeriodontitisPolymorphism
原始语种摘要: Abstract(#br)Periodontitis is considered an inflammatory disorder of bacterial etiology that results in periodontal tissue destruction, as a result of complex interactions between periodontal pathogens, host and immune response. Genetic and epigenetic mechanisms may modulate the individual response since it is able to influence the gene expression. The aim of this study was to evaluate the impact of −174 G/C polymorphism and the methylation status of the promoter region of IL -6 gene on the expression of IL-6 in gingival samples from individuals with chronic periodontitis. Gingival biopsies were collected from 21 patients with chronic periodontitis and 21 controls. Histologic sections stained by hematoxylin–eosin were used for histopathological evaluation. The IL-6 gene expression was...
全文获取路径: Elsevier  (合作)
影响因子:2.814 (2012)

  • periodontal 牙周病学
  • periodontitis 牙周炎
  • methylation 甲基化酌
  • interleukin 白细胞间介素
  • pattern 模型
  • gingival 齿龈的
  • epigenetic 后成的
  • expression 表示
  • polymorphism 多晶形
  • chronic 延续很长的