Numerous Ontogenetic Roads to Mantle Cell Lymphoma: Immunogenetic and Immunohistochemical Evidence
作者: Evi PouliouAliki XochelliGeorge KanellisEvangelia StalikaLesley-Ann SuttonAlba NavarroAndreas AgathangelidisKypros DimosthenousAchilles AnagnostopoulosEfstratios PatsourisPenelope KorkolopoulouChrister SundstromPaolo GhiaMaurilio PonzoniBirgitta SanderElias CampoRichard RosenquistAnastasia HadzidimitriouKostas StamatopoulosTheodora Papadaki
作者单位: 1Hematopathology Department, Evangelismos Hospital, Athens, Greece
2Department of Pathology, University of Athens School of Medicine, Athens, Greece
3Institute of Applied Biosciences, Centre for Research and Technology Hellas (CERTH), Thessaloniki, Greece
4Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden
5Department of Pathology, Hospital Clinic, Barcelona, Spain
6Institute of Biomedical Research August Pi i Sunyer, University of Barcelona, Barcelona, Spain
7Division of Molecular Oncology and Department of Onco-Hematology, IRCCS, San Raffaele Scientific Institute and Universita Vita-Salutte San Raffaele, Milan, Italy
8Hematology Department and Hematopoietic Cell Transplantation Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
9Pathology Unit, San Raffaele Scientific Institute, Milan, Italy
10Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet and Karolinska University Hospital, Huddinge, Sweden
11Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
刊名: The American Journal of Pathology, 2017, Vol.187 (7), pp.1454-1458
来源数据库: Elsevier Journal
DOI: 10.1016/j.ajpath.2017.02.017
原始语种摘要: To obtain insight into the ontogeny of mantle cell lymphoma (MCL), we assessed 206 patients from a morphological, immunohistochemical, and immunogenetic perspective. Our series included nodal ( n = 151), extranodal ( n = 28), and primary splenic ( n = 27) MCL cases. Skewing of the immunoglobulin heavy variable (IGHV) gene repertoire was noted, with only four IGHV genes accounting for 46% of cases and approximately 70% of cases (107/154) bearing an imprint of somatic hypermutation (SHM) ranging from minimal to pronounced. Interestingly, a distinctive immunophenotypic and immunogenetic profile was identified for primary splenic MCL, which was enriched for DBA.44-positive cases ( P < 0.001) and used the IGHV1-8 gene more frequently ( P = 0.02) compared to nodal or extranodal cases, alluding...
全文获取路径: Elsevier  (合作)
影响因子:4.522 (2012)