Relevance of chromosomal band 11q13 in oral carcinogenesis: An update of current knowledge
作者: Pablo Ramos-GarcíaIsabel Ruiz-ÁvilaJosé Antonio Gil-MontoyaÁngela AyénLucía González-RuizFrancisco José Navarro-TriviñoMiguel Ángel González-Moles
作者单位: 1School of Dentistry, University of Granada, Granada, Spain
2Servicio de Anatomía Patológica, Complejo Hospitalario San Cecilio, Granada, Spain
3Instituto de Investigación Biosanitaria, Granada, Spain
4School of Medicine, University of Granada, Granada, Spain
5Servicio de Dermatología, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
6Servicio de Dermatología, Complejo Hospitalario San Cecilio, Granada, Spain
刊名: Oral Oncology, 2017, Vol.72 , pp.7-16
来源数据库: Elsevier Journal
DOI: 10.1016/j.oraloncology.2017.04.016
关键词: Oral cancerCarcinogenesis11q13
英文摘要: Abstract(#br)An important event in oral carcinogenesis is the amplification of chromosomal band 11q13, in which numerous oncogenes and some tumor-suppressor genes are localized and frequently co-amplified during the malignant transformation of oral epithelium. The objectives of this study were to review published data on the involvement of 11q13 amplification in oral cancer, to provide an update on novel concepts and terminology related to gene amplification, and to explore the composition of the 11q13 amplicon in OSCC, including its most relevant amplicon cores and potential drivers. We report on the critical oncogenes and tumor-suppressor genes in 11q13 that may play a major role in oral cancer, focusing on their functions, on the characteristics acquired by their amplification, and on...
全文获取路径: Elsevier  (合作)
影响因子:2.695 (2012)

  • carcinogenesis 癌形成
  • chromosomal 染色体的
  • knowledge 知识
  • cancer 癌症
  • current 
  • update 修改