Impact of FOXL2 mutations on signaling in ovarian granulosa cell tumors
作者: Dilys T.H. LeungPeter J. FullerSimon Chu
作者单位: 1Hudson Institute of Medical Research, 27-31 Wright Street, Clayton, VIC 3168, Australia
2Department of Biochemistry and Molecular Biology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Bldg. 77, 23 Innovation Walk, Clayton, VIC 3168, Australia
刊名: International Journal of Biochemistry and Cell Biology, 2016, Vol.72 , pp.51-54
来源数据库: Elsevier Journal
DOI: 10.1016/j.biocel.2016.01.003
关键词: FOXL2OvaryOvarian cancerGranulosa cell tumor
原始语种摘要: Abstract(#br)Granulosa cell tumors (GCT) are unique sex-cord stromal tumors which account for ∼8% of all ovarian malignancies. They exhibit morphological, biochemical and hormonal features similar to proliferating granulosa cells of the preovulatory follicle, including estrogen and inhibin synthesis. A somatic missense mutation in the forkhead box L2 ( FOXL2 ) gene (C134W) is unique to adult GCT, and absent in other ovarian cancers. FOXL2 is a transcription factor that plays a critical role in ovarian function, in particular, proliferation and differentiation of granulosa cells. The molecular mechanisms underlying the pathogenicity of the mutant FOXL2 remain unresolved. Here we review the molecular alterations known to be associated with mutant FOXL2 and the potential signaling...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • ovarian 卵巢的
  • granulosa 肉芽肿
  • signaling 发信号
  • inhibin 抑制素
  • preovulatory 排卵前的
  • estrogen 雌激素
  • forkhead 叉头
  • therapeutic 治疗的
  • somatic 躯体的
  • hormonal 激素的