Discrimination of pre- and post-treatment breast cancer serum using SELDI-TOF MS (surfaced-enhanced laser desorption/ionization-time of flight mass spectrometry)
作者: Stephen M. BeckerBetsy GregoryO.John SemmesRichard DrakeChristine Laronga
作者单位: 1Eastern Virginia Medical School Norfolk, VA, USA
刊名: Journal of the American College of Surgeons, 2004, Vol.199 (3), pp.89-89
来源数据库: Elsevier Journal
DOI: 10.1016/j.jamcollsurg.2004.05.192
原始语种摘要: Abstract(#br)Introduction: Serum protein profiles generated and analyzed by SELDI-TOF MS can distinguish women with breast cancer from normal healthy women. Our objective was to determine if the breast cancer protein profile reverts to a normal pattern after treatment.(#br)Methods: Following IRB approval, serum samples were obtained pre and 6 months post-treatment from women newly diagnosed with breast cancer (Ca) and normal healthy volunteers (NL). The samples were randomly spotted in duplicate onto IMAC-Cu and SAX ProteinchipsTM (Ciphergen) for SELDI-TOF MS. Biomarker Patterns and Biomarker Wizard software (Ciphergen) were used to analyze the protein peaks.(#br)Results: Serum was obtained from 34 women (16 NL and 16matched pre and post Ca treatment). Stage of disease included: 10 stage...
全文获取路径: Elsevier  (合作)

  • breast 胸部
  • treatment 处理
  • ionization 电离化
  • serum 血清
  • TOF Time Of Filling
  • desorption 解吸
  • flight 飞行
  • cancer 癌症
  • enhanced 增强
  • protein 蛋白质