Easy upgrade of the TRACERLab FX C Pro for [ 11 C]carboxylation reactions: Application to the routine production of [1- 11 C]acetate
作者: Stéphane Le HelleixFrédéric DolléBertrand Kuhnast
作者单位: 1CEA, I²BM, Service Hospitalier Frédéric Joliot, Orsay, France
刊名: Applied Radiation and Isotopes, 2013, Vol.82 , pp.7-11
来源数据库: Elsevier Journal
DOI: 10.1016/j.apradiso.2013.06.020
关键词: [1- 11 C]acetateTRACERLab FX C ProCarboxylationPositron emission tomographyPET
原始语种摘要: Abstract(#br)Carbon-11-labeled acetate ([1- 11 C]acetate) is a radiopharmaceutical of importance in clinical practice as well as in preclinical research in cardiology and oncology. Its preparation is based on the [ 11 C]carboxylation reaction of a Grignard reagent with [ 11 C]CO 2 . Most of the commercially available synthesizers are only dedicated to the preparation of [ 11 C]methyl iodide (or [ 11 C]methyl triflate) for the radiomethylation of an appropriate precursor but not for the direct use of cyclotron-produced [ 11 C]CO 2 . Based on the classical [ 11 C]carboxylation reaction and SPE purification, we propose in this technical note a detailed, simple, easy-to-handle and fully reversible modification of the TRACERLab FX C Pro to operate, on demand, [ 11 C]carboxylation reactions,...
全文获取路径: Elsevier  (合作)
影响因子:1.179 (2012)

  • 反酌 程序
  • acetate 醋酸盐
  • carboxylation 羧化
  • iodide 碘化物
  • preclinical 临证前期的
  • radiochemical 放射化学的
  • dedicated 专用
  • cardiology 心病学
  • routine 程序
  • reaction 程序
  • oncology 肿瘤学