Nickel ions bind to HSP90β and enhance HIF-1α-mediated IL-8 expression
作者: Sanki AsakawaRyo OnoderaKoji KasaiYu KishimotoTaiki SatoRyosuke SegawaNatsumi MizunoKouetsu OgasawaraTakahiro MoriyaMasahiro HiratsukaNoriyasu Hirasawa
作者单位: 1Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan
2Department of Immunobiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan
刊名: Toxicology, 2018, Vol.395 , pp.45-53
来源数据库: Elsevier Journal
DOI: 10.1016/j.tox.2018.01.006
关键词: NickelInterleukin 8HSP90HIF-1αHIF-1βTHP-1
原始语种摘要: Abstract(#br)Nickel ions (Ni 2+ ) eluted from biomedical devices cause inflammation and Ni allergy. Although Ni 2+ and Co 2+ elicit common effects, Ni 2+ induces a generally stronger inflammatory reaction. However, the molecular mechanism by which Ni 2+ and Co 2+ induce such different responses remains to be elucidated. In the present study, we compared the effects of Ni 2+ and Co 2+ on the expression of interleukin (IL)-8 in human monocyte THP-1 cells. We report that NiCl 2 but not CoCl 2 induced the expression of IL-8; in contrast, CoCl 2 elicited a higher expression of hypoxia-inducible factor-1α (HIF-1α). The NiCl 2 -induced expression of IL-8 in late phase was blocked by a HIF-1α inhibitor, PX-478, indicating that NiCl 2 targets additional factors responsible for activating HIF-1α....
全文获取路径: Elsevier  (合作)
影响因子:4.017 (2012)

  • expression 表示
  • linker 链接编辑程序
  • proteins 蛋白质
  • induced 感应的
  • additional 追加的
  • inflammation 炎症
  • higher 
  • possible 可能的
  • interaction 相互酌
  • elicit 引出