Genetic variations of TLRs and their association with HPV/EBV, co-infection along with nicotine exposure in the development of premalignant/malignant lesions of the oral cavity in Indian population
作者: Upma SharmaPallavi SinghalKapil BandilRajeshwar PatleAnoop kumarKausar NeyazSurojit BoseAjay Kumar DewanRavi MehrotraVeena SharmaMausumi Bharadwaj
作者单位: 1Division of Molecular Genetics & Biochemistry, Division of Cytopathology, National Institute of Cancer Prevention & Research (ICMR-NICPR), I-7, Sector-39, Noida, India
2National Institute of Biologicals, Noida, Uttar Pradesh, India
3Human Diagnostics R & D, DSS Imagetech Private Limited, New Delhi, India
4Awadh Dental College and Hospital, Kolkata, India
5Department of Surgical Oncology & Department of Research, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, India
6Division of Cytopathology, National Institute of Cancer Prevention & Research (ICMR-NICPR), I-7, Sector-39, Noida, India
7Department of Bioscience and Biotechnology, Banasthali University, Rajasthan, India
刊名: Cancer Epidemiology, 2019, Vol.61 , pp.38-49
来源数据库: Elsevier Journal
DOI: 10.1016/j.canep.2019.05.003
关键词: Toll-like receptors (TLRs)Single nucleotide polymorphisms (SNPs)Human papillomavirus (HPV)Epstein Bar virus (EBV)Oral squamous cell carcinoma (OSCC)Oral cancer (OC)Oral submucous fibrosis (OSMF)Antigen-presenting cells (APCs)
原始语种摘要: Abstract(#br)Background: Despite being most preventable malignancies associated with smoked and smokeless tobacco products, squamous cell carcinoma of oral cavity is one of the most common malignancy in India. The aim of the present study was to evaluate the role of TLRs in oral pre-cancerous, cancerous cases and their genotypic correlation with HPV/EBV, co-infection & lifestyle habits in Indian population.(#br)Methods: The present study was conducted on 300 subjects (100 OSCC, 50 pre-cancer & 150 controls). The amplification of TLRs gene and HPV/EBV co-infection was assessed by Nested PCR, PCR–RFLP and further confirmation by direct sequencing.(#br)Results: The TLR 9(−1486 T/C), revealed that the TT vs. CT + CC genotype had a ˜5-fold increased risk for the development of pre-cancerous...
全文获取路径: Elsevier  (合作)
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影响因子:2.232 (2012)

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关键词翻译
关键词翻译
  • EBV Extended Binary Vectors
  • premalignant 恶变前的
  • cancerous 癌性的
  • infection 感染
  • papillomavirus 乳头状瘤病毒
  • squamous 具鳞的
  • development 开发
  • carcinoma 癌症
  • leukoplakia 粘膜白斑病
  • Indian 印弟安星座