Comparison of chronological changes in urinary function in patients who underwent low-dose-rate brachytherapy for prostate cancer—A randomized controlled trial of alpha-1 adrenoceptor antagonist alone versus combination with cyclooxygenase-2 inhibitor—
作者: Nobumichi TanakaKazumasa TorimotoIsao AsakawaMakito MiyakeSatoshi AnaiYasushi NakaiTomomi FujiiMasatoshi HasegawaKiyohide Fujimoto
作者单位: 1Department of Urology, Nara Medical University, Kashihara, Nara, Japan
2Department of Radiation Oncology, Nara Medical University, Kashihara, Nara, Japan
3Department of Diagnostic Pathology, Nara Medical University, Kashihara, Nara, Japan
刊名: Brachytherapy, 2018, Vol.17 (3), pp.537-543
来源数据库: Elsevier Journal
DOI: 10.1016/j.brachy.2017.12.004
关键词: Prostate cancerBrachytherapyCOX-2 inhibitorUrinary morbidityFrequency volume chartRandomized controlled trial
英文摘要: Abstract(#br)Purpose(#br)To evaluate the add-on efficacy of a cyclooxygenase (COX)-2 inhibitor on the chronological changes in urinary function in patients who underwent low-dose-rate prostate brachytherapy.(#br)Methods and Materials(#br)A total of 310 patients with prostate cancer who underwent low-dose-rate-brachytherapy were enrolled. Patients were randomized and allocated to the monotherapy group (tamsulosin alone: 0.2 mg/d) and the combination group (tamsulosin 0.2 mg/d plus celecoxib: 200 mg/d). We compared the chronological change in the international prostate symptom score (IPSS), the overactive bladder symptom score (OABSS), uroflowmetric parameters, and the frequency volume chart.(#br)Results(#br)There was not a significant difference between the two groups in the chronological...
全文获取路径: Elsevier  (合作)
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影响因子:1.22 (2012)

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关键词翻译
关键词翻译
  • adrenoceptor 肾上腺素能受体
  • controlled 受控
  • urinary 尿的
  • trial 试验
  • versus 
  • prostate 前列腺
  • brachytherapy 近距放射疗法
  • alone 单独地
  • alpha 接字母顺序的
  • antagonist 对抗剂