Prognostic and clinicopathological significance of cyclin D1 expression in oral squamous cell carcinoma: A systematic review and meta-analysis
作者: Pablo Ramos-GarcíaMiguel Ángel González-MolesLucía González-RuizIsabel Ruiz-ÁvilaÁngela AyénJosé Antonio Gil-Montoya
作者单位: 1School of Dentistry, University of Granada, Granada, Spain
2Instituto de Investigación Biosanitaria, Granada, Spain
3Servicio de Dermatología, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
4Servicio de Anatomía Patológica, Complejo Hospitalario Universitario de Granada, Granada, Spain
5School of Medicine, University of Granada, Granada, Spain
刊名: Oral Oncology, 2018, Vol.83 , pp.96-106
来源数据库: Elsevier Journal
DOI: 10.1016/j.oraloncology.2018.06.007
关键词: Cyclin D1CCND1Oral cancerPrognosisMeta-analysis
原始语种摘要: Abstract(#br)Objectives(#br)To evaluate the prognostic significance of cyclin D1 (CD1) overexpression in OSCC.(#br)Material and methods(#br)We searched studies published before August 2017 (Pubmed, Embase, Web of Science, Scopus). We evaluated the quality of the studies included (Quality in Prognosis Studies [QUIPS] tool). The impact of CD1 overexpression on overall survival and disease-free survival, T status, N status, stage, and histological degree was meta-analyzed. We analyzed heterogeneity among studies, conducted sensitivity analyses, analyzed small-study effects, and conducted subgroup analyses.(#br)Results(#br)31 studies (2942 patients) met inclusion criteria. Qualitative evaluation demonstrated that not all studies were performed with the same rigor, finding the greatest risk of...
全文获取路径: Elsevier  (合作)
影响因子:2.695 (2012)

  • cyclin 细胞周期蛋白
  • squamous 具鳞的
  • carcinoma 癌症
  • analysis 分析
  • significance 显著性
  • systematic 有系统的
  • expression 表示
  • review 复审
  • cancer 癌症