Viewing the Eph receptors with a focus on breast cancer heterogeneity
作者: Ilias NikasHan Suk RyuStamatios Theocharis
作者单位: 1First Department of Pathology, Medical School, University of Athens, Athens, Greece
2School of Medicine, European University Cyprus, Nicosia, Cyprus
3Department of Pathology, Seoul National University Hospital, Seoul, Republic of Korea
刊名: Cancer Letters, 2018, Vol.434 , pp.160-171
来源数据库: Elsevier Journal
DOI: 10.1016/j.canlet.2018.07.030
关键词: ERHER2Triple negative breast cancerBasal-like breast cancerEphrinTargeted therapy
原始语种摘要: Abstract(#br)Aberrant expression of different family members of the Eph/ephrin system, which comprises the Eph receptors (Ephs) and their ligands (ephrins), has been implicated in various malignancies including breast cancer. The latter presents as a heterogeneous disease with diverse molecular, morphologic and clinical behavior signatures. This review reflects the existing Eph/ephrin literature while focusing on breast cancer heterogeneity. Hormone positive, HER2 positive and triple negative breast cancer (TNBC) cell lines, xenografts/mutant animal models and patient samples are examined separately as, in humans, they represent entities with differences in prognosis and treatment. EphA2, EphB4 and EphB6 are the members most extensively studied in breast cancer. Existing research points...
全文获取路径: Elsevier  (合作)
影响因子:4.258 (2012)

  • focus 焦点
  • heterogeneity 不均匀性
  • breast 胸部
  • cancer 癌症