Epstein-Barr Virus dUTPase Induces Neuroinflammatory Mediators: Implications for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
作者: Marshall V. Williams PhDBrandon CoxWilliam P. Lafuse PhDMaria Eugenia Ariza
作者单位: 1Department of Cancer Biology and Genetics, The Ohio State University Wexner Medical Center, Columbus, OH, USA
2Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, Columbus, OH, USA
3Department of Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH, USA
刊名: Clinical Therapeutics, 2019, Vol.41 (5), pp.848-863
来源数据库: Elsevier Journal
DOI: 10.1016/j.clinthera.2019.04.009
关键词: Deoxyuridine triphosphate nucleotidohydrolase (dUTPase)Epstein-Barr virus (EBV)Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)Synaptic plasticityToll-like receptor 2 (TLR2)
英文摘要: Abstract(#br)Purpose(#br)Neuroinflammation is a common feature in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), affecting 85%–90% of all patients, yet the underlying mechanism or mechanisms responsible for the initiation and/or promotion of this process is largely unknown. Multiple reports, however, have suggested a role for Epstein-Barr virus (EBV), in particular, in ME/CFS, but its potential role, if any, in the neuroinflammatory process has not been addressed. In support of this premise, studies by our group have found that the EBV protein deoxyuridine triphosphate nucleotidohydrolase (dUTPase) induces anxiety and sickness behaviors in female mice. We also found that a small subset of patients with ME/CFS exhibited prolonged and significantly elevated neutralizing...
全文获取路径: Elsevier  (合作)
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影响因子:2.23 (2012)

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