Comprehensive expression analysis of TNF-related apoptosis-inducing ligand and its receptors in colorectal cancer: Correlation with MAPK alterations and clinicopathological associations
作者: Spyridon TsikalakisIlenia ChatziandreouNikolaos V. MichalopoulosGeorgios E. TheodoropoulosStratigoula SakellariouPenelope KorkolopoulouEfstratios PatsourisAngelica A. Saetta
作者单位: 11st Dept. of Pathology, National and Kapodistrian University of Athens, School of Medicine, Mikras Asias 75, Athens, Goudi, Greece
21st Department of Propaedeutic Surgery Hippokrateion Hospital, National and Kapodistrian University of Athens, School of Medicine, Vas Sofias 114, Athens, Greece
刊名: Pathology - Research and Practice, 2018, Vol.214 (6), pp.826-834
来源数据库: Elsevier Journal
DOI: 10.1016/j.prp.2018.04.019
关键词: TRAILApoptosisMRNA expressionReal time RT-PCRColorectal cancer
原始语种摘要: Abstract(#br)TNF-related, apoptosis-inducing ligand (TRAIL) apoptotic pathway constitutes a promising therapeutic target due to high selectivity and low toxicity of TRAIL targeting agents when administered in combination therapies. 106 colorectal cancers were examined for: relative mRNA expression of TRAIL pathway genes, decoy receptors TRAIL-R3 and TRAIL-R4 promoter methylation and the presence of KRAS, NRAS, BRAF mutations. Elevated mRNA levels were observed in 26%, 15%, 13%, 12% and 10% of the cases for TRAIL-R4, TRAIL-R3, TRAIL-R2, TRAIL-R1 and TRAIL genes respectively. Reduced mRNA levels were detected in 77%, 65%, 64%, 60% and 37% of the cases for TRAIL, TRAIL-R2, TRAIL-R3, TRAIL-R1 and TRAIL-R4 genes respectively. TRAIL-R3 and TRAIL-R4 promoter methylation was detected in 55% and...
全文获取路径: Elsevier  (合作)
影响因子:1.213 (2012)

  • colorectal 结肠直肠的
  • expression 表示
  • correlated 相关
  • ligand 配合体
  • cancer 癌症
  • pathway 轨道
  • apoptosis 细胞死
  • mRNA m核糖核酸
  • targeting 导向目标
  • targeted 对准目标的