Chimeric mice with humanized liver: Application in drug metabolism and pharmacokinetics studies for drug discovery
作者: Yoichi NaritomiSeigo SanohShigeru Ohta
作者单位: 1Analysis & Pharmacokinetics Research Laboratories, Astellas Pharma Inc., Ibaraki, Japan
2Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
刊名: Drug Metabolism and Pharmacokinetics, 2018, Vol.33 (1), pp.31-39
来源数据库: Elsevier Journal
DOI: 10.1016/j.dmpk.2017.11.001
关键词: Chimeric mice with humanized liverPredictionDrug metabolismPharmacokineticsMetabolite profilesDrug-drug interactions
英文摘要: Abstract(#br)Predicting human drug metabolism and pharmacokinetics (PK) is key to drug discovery. In particular, it is important to predict human PK, metabolite profiles and drug-drug interactions (DDIs). Various methods have been used for such predictions, including in vitro metabolic studies using human biological samples, such as hepatic microsomes and hepatocytes, and in vivo studies using experimental animals. However, prediction studies using these methods are often inconclusive due to discrepancies between in vitro and in vivo results, and interspecies differences in drug metabolism. Further, the prediction methods have changed from qualitative to quantitative to solve these issues. Chimeric mice with humanized liver have been developed, in which mouse liver cells are mostly...
全文获取路径: Elsevier  (合作)
影响因子:2.071 (2012)

  • humanized 人化的
  • liver 
  • metabolism 代谢
  • discovery 发现
  • Application 应用