Regulation of TIMP-1 phenotypic expression in Epstein–Barr virus-immortalized B lymphocytes
作者: Candice TrocméPhilippe GaudinSylvie BerthierFrançoise Morel
作者单位: 1GREPI, Laboratoire d'Enzymologie, CHU Albert Michallon, BP 217, 38043 Grenoble Cedex 9, France
2Service de Rhumatologie, CHU Albert Michallon, Grenoble, France
刊名: BBA - Molecular Cell Research, 2002, Vol.1590 (1), pp.167-176
来源数据库: Elsevier Journal
DOI: 10.1016/S0167-4889(02)00210-0
关键词: B lymphocyteEpstein–Barr virusPhenotypic regulationTIMPMatrix metalloproteinaseIon movement
原始语种摘要: Abstract(#br)Normal B lymphocytes as well as malignant B cells extravasate from blood circulation during physiological and pathological processes and require matrix metalloproteinases (MMPs) to facilitate trafficking through the subendothelial basal lamina and the extracellular matrix. We have previously shown that Epstein–Barr virus (EBV)-immortalized B lymphocytes constitutively synthesized low levels of MMP-9 and huge amounts of its preferential inhibitor, tissue inhibitor of matrix metalloproteinase-1 (TIMP-1). In the present study, TIMP-1 phenotypic expression was extensively investigated in response to various mediators including interleukins, chemokines, growth factors and tumor promotor, and was compared to MMP-9 synthesis. Results showed a roughly constitutive TIMP-1 expression...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • phenotypic 表型的
  • expression 表示
  • virus 病毒
  • regulation 
  • lymphocyte 淋巴细胞
  • extravasate 外渗
  • subendothelial 内皮下的
  • monensin 莫能菌素
  • synthesis 合成
  • intracellular 胞内的