Potential role for the VDR agonist elocalcitol in metabolic control: Evidences in human skeletal muscle cells
作者: Cristina AntinozziClarissa CorinaldesiCarla GiordanoAnnalinda PisanoBruna CerbelliSilvia MigliaccioLuigi Di LuigiKatia StefanantoniGabriella Barbara VannelliSalvatore MinisolaGuido ValesiniValeria RiccieriAndrea LenziClara Crescioli
作者单位: 1Department of Movement, Human and Health Sciences, University of Rome Foro Italico, 00135 Rome, Italy
2Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, 00161 Rome, Italy
3Department of Internal Medicine and Medical Specialities, Sapienza University of Rome, 00161 Rome, Italy
4Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy
5Department of Internal Medicine and Medical Disciplines, Sapienza University of Rome, 00161 Rome, Italy
6Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy
7Leeds Institute of Rheumatic & Musculoskeletal Medicine, University of Leeds, Leeds, UK
刊名: Journal of Steroid Biochemistry and Molecular Biology, 2017, Vol.167 , pp.169-181
来源数据库: Elsevier Journal
DOI: 10.1016/j.jsbmb.2016.12.010
关键词: VDR agonistMetabolismInflammatory myopathyHuman skeletal muscle cells
原始语种摘要: Abstract(#br)Vitamin D plays a pivotal role to maintain skeletal muscle integrity and health. Vitamin D deficiency characterizes inflammatory myopathy (IM) and diabetes, often overlapping diseases involving skeletal muscle damage. Vitamin D receptor (VDR) agonists likely exert beneficial effects in both IM and metabolic disturbances. We aim to evaluate in vitro the effect of elocalcitol, a non-hypercalcemic VDR agonist, on the biomolecular metabolic machinery of human skeletal muscle cells (Hfsmc), vs. insulin (I). We analyzed GLUT4, Flotillin-1, Caveolin-3 and Caveolin-1 cell expression/localization; mTOR, AKT, ERK and 4E-BP1 phosphorylation; IL-6 myokine release; VDR expression. We investigated in vivo vitamin D status in IM subjects, evaluating VDR muscular expression and serum vitamin...
全文获取路径: Elsevier  (合作)

  • muscle 肌肉
  • metabolic 新陈代谢的
  • cells 麻风细胞
  • resistin 一种锰铜电阻合金
  • VDR Validated Data Record
  • normoglycemic 血糖量正常的
  • glycemia 血糖
  • agonist 织肌
  • human 人的
  • skeletal 骨架