Efficient production of bioactive metabolites from Antrodia camphorata ATCC 200183 by asexual reproduction-based repeated batch fermentation
作者: Hua-Xiang LiZhen-Ming LuYan GengJin-Song GongXiao-Juan ZhangJin-Song ShiZheng-Hong XuYan-He Ma
作者单位: 1School of Pharmaceutical Science, Jiangnan University, Wuxi 214122, PR China
2Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, PR China
3Tianjin Key Laboratory for Industrial Biological Systems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 214122, PR China
刊名: Bioresource Technology, 2015, Vol.194 , pp.334-343
来源数据库: Elsevier Journal
DOI: 10.1016/j.biortech.2015.06.144
关键词: Antrodia camphorataAntrodinArthroconidiumRepeated batch fermentation
原始语种摘要: Abstract(#br)Large-scale submerged fermentation (SmF) of Antrodia camphorata ( A. camphorata ) usually encounters challenges including tedious preparation of mycelial inoculum, long fermentation period (10–14d), and poor repeatability. Here we developed an asexual reproduction-based repeated batch fermentation (RBF) process for bioactive metabolites production by A. camphorata ATCC 200183. Compared with traditional batch fermentation, production time was shortened to 58d from 80d (overall time for eight cycles) using the RBF process established in this study, and accordingly, the productivities of bioactive metabolites (including antrodins) were improved by 40–60%. Kinetic parameters ( α is 2.1–18.7 times as β ) indicated that the...
全文获取路径: Elsevier  (合作)
影响因子:4.75 (2012)

  • batch 一批
  • fermentation 发酵
  • production 生产
  • bioactive 对活质起作用的
  • repeated 重复的
  • asexual 无性的
  • based 基于