Cathepsin S inhibition changes regulatory T-cell activity in regulating bladder cancer and immune cell proliferation and apoptosis
作者: Xiang YanChun WuTao ChenMarcela M. SantosCong-Lin LiuChongzhe YangLijun ZhangJingyuan RenSha LiaoHongqiang GuoGalina K. SukhovaGuo-Ping Shi
作者单位: 1Department of Urology, Drum Tower Hospital, Nanjing University Medical School, Nanjing, 210008, China
2Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA
3Department of Cardiology, Institute of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and technology, Wuhan, 430022, China
刊名: Molecular Immunology, 2017, Vol.82 , pp.66-74
来源数据库: Elsevier Journal
DOI: 10.1016/j.molimm.2016.12.018
关键词: Regulatory T-cellBladder cancerSplenocytesCathepsin SProliferationApoptosis
原始语种摘要: Abstract(#br)Regulatory T cells (Tregs) are immune suppressive cells, but their roles in tumor growth have been elusive, depending on tumor type or site. Our prior study demonstrated a role of cathepsin S (CatS) in reducing Treg immunosuppressive activity. Therefore, CatS inhibition in Tregs may exacerbate tumor growth. Using mouse bladder carcinoma MB49 cell subcutaneous implant tumor model, we detected no difference in tumor growth, whether mice were given saline- or CatS inhibitor-treated Tregs. However, mice that received inhibitor-treated Tregs had fewer splenic and tumor Tregs, and lower levels of tumor and splenic cell proliferation than mice that received saline-treated Tregs. In vitro , inhibitor-treated Tregs showed lower proliferation and higher apoptosis than saline-treated...
全文获取路径: Elsevier  (合作)
影响因子:2.645 (2012)

  • bladder 膀胱
  • inhibition 抑制
  • saline 盐的
  • immune 免疫的
  • apoptosis 细胞死
  • regulatory 控制的
  • proliferation 增生
  • treated 加工的
  • conditioned 经过调节的
  • cancer 癌症