The emerging role of intraoperative flow cytometry in intracranial tumor surgery
作者: George A AlexiouGeorge VartholomatosTatsuya KobayashiSpyridon VoulgarisAthanasios P Kyritsis
作者单位: 1Department of Neurosurgery, University Hospital of Ioannina, Greece
2Neurosurgical Research Institute, University of Ioannina, Greece
3Department of Hematology-Unit of Molecular Biology, University Hospital of Ioannina, Greece
4Department of Neurosurgery, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan
5Faculty of Advanced Techno-Surgery, Institute of Advanced Biomedical Engineering & Science, Graduate School of Medicine, Tokyo Women's Medical University, Tokyo, Japan
6Department of Neurology, University Hospital of Ioannina, Ioannina, Greece
刊名: Clinical Neurology and Neurosurgery, 2020, Vol.192
来源数据库: Elsevier Journal
DOI: 10.1016/j.clineuro.2020.105742
关键词: Flow cytometryIntraoperativeGliomaResection marginsPrognosis
原始语种摘要: Abstract(#br)Intraoperative flow cytometry has been recently emerged as a novel and promising tool for intracranial tumor surgery. Herewith, we discuss the role of intraoperative flow cytometry for the identification of gliomas boundaries, which may permit maximal resection and better prognosis. We also discuss its role in assessing tumor’s grade of malignancy, both in adults and children and the prognostic information that may provide. Finally, intraoperative immunophenotypic analysis opens new horizons for flow cytometry. By evaluating tumor’s specific cluster differentiation markers a diagnosis, within minutes, of certain tumor type can be achieved and additional information for therapeutic guidance can be provided.
全文获取路径: Elsevier  (合作)
影响因子:1.234 (2012)

  • intracranial 颅内的
  • cytometry 血细胞计数
  • tumor 肿胀
  • malignancy 恶性
  • prognosis 预报
  • guidance 制导
  • resection 后方交会
  • therapeutic 治疗的
  • grade 品位
  • discuss 议论