Somatic mutations in exon 17 of the TEK gene in vascular tumors and vascular malformations
作者: Caisheng YeLingxiao PanYongbo HuangRunyi YeAnjia HanSongqi LiXiaoxi LiShenming Wang
作者单位: 1Department of Vascular and Thyroid Surgery, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou City, Guangdong Province, China
2Department of Breast Surgery, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou City, Guangdong Province, China
3Department of Pathology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou City, Guangdong Province, China
刊名: Journal of Vascular Surgery, 2011, Vol.54 (6), pp.1760-1768.e3
来源数据库: Elsevier Journal
DOI: 10.1016/j.jvs.2011.06.098
原始语种摘要: Objective(#br)As a common disease, the molecular etiology of noninherited vascular anomalies is still poorly understood. Recently, somatic mutations in exon 17 of the endothelial cell tyrosine kinase receptor Tie-2 (encoded by TEK) were identified in 49.1% of patients with common sporadic venous malformation, a subtype of vascular anomalies. We assessed whether such a mutational region also had a role in the Chinese population or in other subtypes of noninherited vascular anomalies (vascular tumors and vascular malformations).(#br)Methods(#br)Direct sequencing of polymerase chain reaction (PCR)-amplified DNA, extracted from 139 lesions in 129 individuals with noninherited vascular anomalies (vascular tumors or vascular malformations) and 60 control samples, was used for detecting the...
全文获取路径: Elsevier  (合作)
分享到:
来源刊物:
影响因子:2.879 (2012)

×
关键词翻译
关键词翻译
  • vascular 维管的
  • arteriovenous 动静脉的
  • malformation 畸形
  • capillary 毛状的
  • somatic 躯体的
  • etiology 病原学
  • hemangioma 血管瘤
  • common 普通
  • granuloma 肉芽肿
  • previously 以前