Impact of influenza vaccine-modified infectivity on attack rate, case fatality ratio and mortality
 作者： Kyeongah Nah,  Mahnaz Alavinejad,  Ashrafur Rahman,  Jane M Heffernan,  Jianhong Wu 作者单位： 1Laboratory for Industrial and Applied Mathematics, York University, Toronto, ON M3J 1P3, Canada2Department of Mathematics and Statistics, York University, Toronto, ON M3J 1P3, Canada3Department of Mathematics and Statistics, Oakland University, Rochester, MI 48309, USA4Centre for Disease Modelling (CDM), York University, Toronto, ON M3J 1P3, Canada5Fields-CQAM Laboratory of Mathematics for Public Health, York University, Toronto, ON M3J 1P3, Canada 刊名： Journal of Theoretical Biology, 2020, Vol.492 来源数据库： Elsevier Journal DOI： 10.1016/j.jtbi.2020.110190 关键词： Attack rate;  Attack ratio;  Influenza virus;  Vaccination impact;  Mathematical modelling; 原始语种摘要： Abstract(#br)Generally, vaccines are designed to provide protection against infection (susceptibility), disease (symptoms and transmissibility), and/or complications. In a recent study of influenza vaccination, it was observed that vaccinated yet infected individuals experienced increased transmission levels. In this paper, using a mathematical model of infection and transmission, we study the impact of vaccine-modified effects, including susceptibility and infectivity, on important epidemiological outcomes of an immunization program. The balance between vaccine-modified susceptibility, infectivity and recovery needed in preventing an influenza outbreak, or in mitigating the health outcomes of the outbreak is studied using the SIRV -type of disease transmission model. We also investigate... the impact of influenza vaccination program on the infection risk of vaccinated and non-vaccinated individuals.

• infectivity　传染性
• influenza　列性感冒
• vaccine　菌苗
• vaccinated　接种疫苗的
• virus　病毒
• ratio
• susceptibility　磁化率
• vaccination　注射疫苗
• fatality　致死率
• impact　冲击碰撞