Impact of influenza vaccine-modified infectivity on attack rate, case fatality ratio and mortality
作者: Kyeongah NahMahnaz AlavinejadAshrafur RahmanJane M HeffernanJianhong Wu
作者单位: 1Laboratory for Industrial and Applied Mathematics, York University, Toronto, ON M3J 1P3, Canada
2Department of Mathematics and Statistics, York University, Toronto, ON M3J 1P3, Canada
3Department of Mathematics and Statistics, Oakland University, Rochester, MI 48309, USA
4Centre for Disease Modelling (CDM), York University, Toronto, ON M3J 1P3, Canada
5Fields-CQAM Laboratory of Mathematics for Public Health, York University, Toronto, ON M3J 1P3, Canada
刊名: Journal of Theoretical Biology, 2020, Vol.492
来源数据库: Elsevier Journal
DOI: 10.1016/j.jtbi.2020.110190
关键词: Attack rateAttack ratioInfluenza virusVaccination impactMathematical modelling
原始语种摘要: Abstract(#br)Generally, vaccines are designed to provide protection against infection (susceptibility), disease (symptoms and transmissibility), and/or complications. In a recent study of influenza vaccination, it was observed that vaccinated yet infected individuals experienced increased transmission levels. In this paper, using a mathematical model of infection and transmission, we study the impact of vaccine-modified effects, including susceptibility and infectivity, on important epidemiological outcomes of an immunization program. The balance between vaccine-modified susceptibility, infectivity and recovery needed in preventing an influenza outbreak, or in mitigating the health outcomes of the outbreak is studied using the SIRV -type of disease transmission model. We also investigate...
全文获取路径: Elsevier  (合作)
影响因子:2.351 (2012)

  • infectivity 传染性
  • influenza 列性感冒
  • vaccine 菌苗
  • vaccinated 接种疫苗的
  • virus 病毒
  • ratio 
  • susceptibility 磁化率
  • vaccination 注射疫苗
  • fatality 致死率
  • impact 冲击碰撞