Association of Atrial Natriuretic Peptide and Type A Natriuretic Peptide Receptor Gene Polymorphisms With Left Ventricular Mass in Human Essential Hypertension
作者: Speranza RubattuGiada BigattiAnna EvangelistaChiara LanzaniRosita StanzioneLaura ZagatoPaolo ManuntaSimona MarchittiVanessa VenturelliGiuseppe BianchiMassimo VolpePaola Stella
作者单位: 1IRCCS Neuromed, Polo Molisano University of Rome La Sapienza, Pozzilli, Italy
2U.O. Cardiologia, II nd School of Medicine, University of Rome La Sapienza, S. Andrea Hospital, Rome, Italy
3Division of Nephrology, Dialysis and Hypertension, University Vita e Salute, San Raffaele Hospital, Milan, Italy.
刊名: Journal of the American College of Cardiology, 2006, Vol.48 (3), pp.499-505
来源数据库: Elsevier Journal
DOI: 10.1016/j.jacc.2005.12.081
原始语种摘要: Objectives(#br)The goal of our study was to investigate the relationships between atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and type A natriuretic peptide receptor (NPRA) gene polymorphisms and left ventricular structure in human essential hypertension.(#br)Background(#br)Experimental evidence supports a key role for natriuretic peptides in the modulation of cardiac mass. This relationship has not yet been described in human disease.(#br)Methods(#br)A total of 203 hypertensive patients were studied by mono-bidimensional echocardiography. Three markers of the ANP gene (−C664G, G1837A, and T2238C polymorphisms) and a microsatellite marker of both NPRA and BNP genes were characterized.(#br)Results(#br)Patients carrying the ANP gene promoter allelic variant had...
全文获取路径: Elsevier  (合作)
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影响因子:14.086 (2012)

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关键词翻译
关键词翻译
  • natriuretic 促尿钠排泄的
  • hypertensive 高血压的
  • hypertension 高血压
  • septal 中隔的
  • Association 美国公共卫生协会
  • ventricular 室的
  • essential 本质的
  • markers 时标
  • peptide 
  • allelic 等位的