A polyphenol-metal nanoparticle platform for tunable release of liraglutide to improve blood glycemic control and reduce cardiovascular complications in a mouse model of type II diabetes
作者: Zhiyu HeTianqi NieYizong HuYang ZhouJinchang ZhuZhijia LiuLixin LiuKam W. LeongYongming ChenHai-Quan Mao
作者单位: 1School of Materials Science and Engineering, Center for Functional Biomaterials, and Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-sen University, Guangzhou 510275, China
2Department of Materials Science and Engineering, Whiting School of Engineering, USA
3Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA
4Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
5Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
6Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
刊名: Journal of Controlled Release, 2020, Vol.318 , pp.86-97
来源数据库: Elsevier Journal
DOI: 10.1016/j.jconrel.2019.12.014
关键词: Ternary nanoparticlesTannic acidAluminumLiraglutideSustained releaseType-II diabetes
英文摘要: Abstract(#br)Liraglutide is a GLP-1 receptor agonist recently approved for Type-II diabetes (T2D) treatment with superior hypoglycemic effect while also improving cardiovascular function for the patients. However, its application has been limited by its short half-life (~13 h), which requires daily injections to maintain effective drug concentrations in blood, thus increasing the risk of poor patient compliance and complications. In this study, we developed a ternary liraglutide/tannic acid (TA)/Al 3+ nanoparticle system based on hydrogen bond formation between liraglutide and TA and stabilized by complex coordination interaction between TA and Al 3+ . This ternary nanoparticle formulation offers sustained release of liraglutide for >8 days by optimizing the concentration of TA during...
全文获取路径: Elsevier  (合作)
影响因子:7.633 (2012)

  • diabetes 糖尿病
  • polyphenol 多元酚
  • release 释放
  • cardiovascular 心血管的
  • mouse 小鼠
  • platform 台地
  • tunable 可(协)调
  • improve 改进
  • blood 血液
  • nanoparticle 乳酸